Perioperative medicine & outcomes
Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial
Authors' conclusion
Delirium was a third less common after propofol than sevoflurane anaesthesia in older patients having major cancer surgery.
Study context
- Population
- Patients aged 65–90 yr undergoing major cancer surgery, 14 tertiary care hospitals in China1,195 in modified ITT analysis
- Participants
- 1,228 patients
- Comparison
- Propofol-based vs sevoflurane-based anaesthesia
- Propofoln = 597
- Sevofluranen = 597reference
- Primary endpoint
- Incidence of delirium
- Follow-up
- Within 7 postoperative days
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Each group vs sevofluraneEstimate (95% CI)P value
Propofol
RR 0.68(0.48–0.95)
P = 0.023Propofol
adjusted RR 0.59(0.39–0.90)
P = 0.014Secondary outcomes
| Outcome | Propofol | Sevoflurane | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Delirium on first POD · first day after surgery | 5.4% | 10.7% | 0.50 (0.33–0.75) | P = 0.001 | |
| 0.20.5125Relative risk (log scale) |
ICU admission, postoperative hospital LOS, major complications within 30 days, cognitive function at 30 days and 3 yr
- Did not differ significantly between groups
Safety
Safety outcomes
- Did not differ significantly between groups
Original publication
Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial. Br J Anaesth. Published 4 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →