Long-term survival in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: follow-up of a multicentre randomised trial
Primary result · DeathsResult — go to the resultAdjusted hazard ratio 1.02 95% CI 0.83–1.26Authors' conclusion
Long-term survival after major cancer surgery was similar with i.v. and volatile anaesthesia.
Study context
- Population
- Patients aged 65–90 yr scheduled for major cancer surgery, 14 tertiary hospitals in China1,195 in modified ITT analysis
- Participants
- 1,228 patients
- Comparison
- Propofol vs Sevoflurane
- Propofoln = 598
- Sevofluranen = 597reference
- Primary endpoint
- Overall survival after surgery
Methodological details14 tertiary hospitals
- 14 tertiary hospitals
Primary result
Deaths · median 43 months follow-up
Adjusted hazard ratio
1.02
95% CI 0.83–1.26
P = 0.834
Events by treatment group
Propofol vs Sevoflurane
adjusted HR 1.02 (95% CI 0.83–1.26); P = 0.834
As reported in the abstract
Secondary outcomes
| Outcome | Propofol | Sevoflurane | Estimate | P value | |
|---|---|---|---|---|---|
| Recurrence-free survival · median 43 monthsModified ITT | 37% | 35% | adjusted HR for recurrence or death 1.07 (95% CI 0.89–1.30) | P = 0.465 | |
| Event-free survival · median 43 monthsModified ITT | 49% | 46% | adjusted HR for an event 1.09 (95% CI 0.93–1.29) | P = 0.298 | |
| 0.512Ratio (log scale) |
Original publication
Long-term survival in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: follow-up of a multicentre randomised trial. Br J Anaesth. Published 4 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →