Demographics and outcome of Legionella pneumonia in the intensive care unit: a retrospective multicenter cohort study
Main finding · 28-day mortalityResult — go to the resultOdds ratio 1.24 CI 0.49–3.05Authors' conclusion
Patients suffering from LP requiring ECMO support had similar mortality rates compared to LP patients without ECMO support, despite higher SOFA scores.
Study context
- Population
- ICU patients with Legionella pneumonia at three tertiary university hospitals (Zurich, Hannover, Bonn), 2013 to 2023Extracorporeal membrane oxygenation (ECMO) in 40%
- Participants
- 110 patients
- Exposure
- ECMO vs no ECMO
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Odds ratio
1.24
CI 0.49–3.05
P = 0.64
By group
ECMO vs Without ECMO
OR 1.24 (CI 0.49–3.05); P = 0.64
Observational data: associations, not effects.
Further findings
Independent risk factors for 28-day mortality (multivariable analysis)
| OR (CI) | P value | ||
|---|---|---|---|
| Hospital-acquired LPMultivariable analysis | 28.4 (3.44–614) | P = 0.006 | |
| LactateMultivariable analysis | 1.31 (1.05–1.75) | P = 0.031 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | ECMO | Without ECMO | P value |
|---|---|---|---|
| SOFA score 24 h after ICU admission | 12 | 9 | P < 0.001 |
Adequate antibiotic legionella pneumonia (LP) coverage at ICU admission
- Adequate antibiotic coverage in 57% of patients, with no differences in outcome
Original publication
Demographics and outcome of Legionella pneumonia in the intensive care unit: a retrospective multicenter cohort study. Crit Care. Published 20 August 2025. doi:10.
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