Determinants of beta-lactam PK/PD target attainment in critically ill patients: A single center retrospective study
Authors' conclusion
Achieving target BL plasma concentrations remains challenging in ICUs.
Study context
- Population
- ICU patients with at least one beta-lactam therapeutic drug monitoring
- Participants
- 156 patients
- Outcome
- Attainment of recommended beta-lactam plasma concentrations (100%fT > 4 to 8 MIC) and its determinants
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Beta-lactam target attainment · First dosing
- Achieved target plasma concentrations
- 34%
- Overdosed
- 50%
- Underdosed
- 16%
- CKD-EPI eGFR as determinant of target attainment (multivariate), OR
- 1.02; CI [1.01; 1.03]; p < 0.0001
- Total body weight as determinant of target attainment (multivariate), OR
- 1.03; CI [1.01; 1.04]; p = 0.0048
- CRRT as risk factor for overdosing, OR
- 0.28; CI [0.09; 0.89]; p = 0.0318
- Meropenem use as risk factor for overdosing, OR
- 0.31; CI [0.14; 0.69]; p = 0.0041
Observational data: associations, not effects.
Further findings
Time to first therapeutic drug monitoring (TDM)
- Median time to 1st TDM, days (SD = 2.9)
- 4
Original publication
Determinants of beta-lactam PK/PD target attainment in critically ill patients: A single center retrospective study. J Crit Care. Published 17 May 2024. doi:10.
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