Development and validation of a model to calculate anesthetic agent consumption from inspired and end-expired concentrations, minute ventilation, fresh gas flow and dead space ventilation
Authors' conclusion
FVAP can be retrospectively calculated from FIN, FET, FGF, and MV plus an agent specific dead space fraction factor with a degree of error that we believe suffices for retrospective sevoflurane consumption analyses.
Study context
- Population
- Patients receiving volatile anesthetics via circle breathing systems (derivation: ADU; validation: sevoflurane in O2/air with FLOW-i and Zeus workstations)prospective validation
- Participants
- 78 patients
- Comparison
- Model-predicted vs dialed vaporizer setting
- Outcome
- Prediction error of FVAP calculated from FIN, FET, FGF and minute ventilation (MV) vs dialed FVAP (MDPE and MDAPE)
Methodological detailsempirical derivation from retrospective data set, prospective validation
- Empirical derivation from retrospective data set
- Prospective validation
Performance
As reported in the abstract
Model prediction of dialed FVAP (sevoflurane, prospective testing)
Median performance error (MDPE), median (IQR) %
−1 (−11, 6) %
Median absolute performance error (MDAPE), median (IQR) %
8 (4, 17) %
Further findings
Empirical dead space fraction (derivation data set, 161 patients)
- Isoflurane
- 0.59
- Sevoflurane
- 0.49
- Desflurane
- 0.66
Original publication
Development and validation of a model to calculate anesthetic agent consumption from inspired and end-expired concentrations, minute ventilation, fresh gas flow and dead space ventilation. J Clin Monit Comput. Published 16 June 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →