Cardiothoracic & vascular anesthesia
Dexamethasone for Cardiac Surgery: A Practice Preference–Randomized Consent Comparative Effectiveness Trial
Primary resultResult — go to the resultMedian difference 0.1 95% CI −0.3 to 0.5Authors' conclusion
Among patients undergoing cardiac surgery, high-dose dexamethasone decreased intensive care unit stay but did not increase the number of home days after surgery.
Study context
- Population
- Patients undergoing cardiac surgery at 7 hospitals in Australia and The Netherlandsrandomized
- Participants
- 1,951 patients
- Comparison
- Dexamethasone 1 mg/kg vs no dexamethasone
- Primary endpoint
- Days alive and at home (home days)
- Follow-up
- Up to 30 days after surgery
Methodological detailspragmatic, international, prerandomized consent design favoring local practice, comparative effectiveness, multicentre
- Pragmatic
- International
- Prerandomized consent design favoring local practice
- Comparative effectiveness
- Multicentre
Primary result
As reported in the abstract
Median difference
0.1
95% CI −0.3 to 0.5
P = 0.66
By group
Dexamethasone vs Control
median difference 0.1 (95% CI −0.3 to 0.5); P = 0.66
Secondary outcomes
ICU stay
- ICU stay: P = 0.004
Prolonged mechanical ventilation (>48 h), sepsis, renal failure, MI, stroke, death (dexamethasone vs control)
- Prolonged mechanical ventilation, RR
- 0.72 (95% CI 0.48 to 1.08)
- Sepsis, RR
- 1.02 (95% CI 0.57 to 1.82)
- Renal failure, RR
- 0.94 (95% CI 0.80 to 1.12)
- MI, RR
- 1.20 (95% CI 0.30 to 4.82)
- Stroke, RR
- 1.06 (95% CI 0.54 to 2.08)
- Death, RR
- 0.72 (95% CI 0.22 to 2.35)
- Comparable between groups
- All P > 0.10
ICU stay
- Dexamethasone reduced ICU stay
Trial design efficiency (enrollment)
- Novel trial design highly efficient (enrollment)
- 89.3%
Original publication
Dexamethasone for Cardiac Surgery: A Practice Preference–Randomized Consent Comparative Effectiveness Trial. Anesthesiology. Published 21 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →