Cardiac arrest & resuscitation
Dexamethasone Versus Placebo in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Study Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest Trial ( Danish Out-of-Hospital Cardiac Arrest (DANOHCA) )
Study context
- Population
- Adult comatose out-of-hospital cardiac arrest (OHCA) survivors with presumed cardiac etiology and sustained ROSCtarget 1000 at 5 sites
- Planned comparison
- High-dose dexamethasone vs placebo
- Primary endpoint
- All-cause mortality (RR of death from any cause, log-binomial regression)
- Follow-up
- 90 days
Methodological detailsinvestigator-initiated, multicentre, blinded, placebo-controlled, 1:1 randomisation, part of a trial evaluating four post-resuscitation interventions, Enrollment began June 2023; planned over 3-4 years
- Investigator-initiated
- Multicentre
- Blinded
- Placebo-controlled
- 1:1 randomisation
- Part of a trial evaluating four post-resuscitation interventions
- Enrollment began June 2023; planned over 3-4 years
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Dexamethasone Versus Placebo in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Study Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest Trial ( DANOHCA ). Acta Anaesthesiol Scand. Published 24 June 2026. doi:10.
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