Cardiac arrest & resuscitation
Prophylactic Olanzapine Versus Placebo in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest ( DANOHCA ) Trial
Study context
- Population
- Comatose adults with Out-of-Hospital Cardiac Arrest (OHCA) of presumed cardiac cause and sustained ROSC (> 20 min)planned 1000 from 5 sites
- Planned comparison
- Prophylactic olanzapine 10 mg vs placebo
- Primary endpoint
- Days alive and out of the hospital
- Follow-up
- 30 days after admission
Methodological detailsinvestigator-initiated, multicentre, placebo-controlled, 1:1 randomisation, part of a trial evaluating four postresuscitation interventions, Inclusion began June 2023; estimated 3-4 years, Primary outcome analysed with Wilcoxon rank-sum test; medians with IQR and 95% CI for median difference
- Investigator-initiated
- Multicentre
- Placebo-controlled
- 1:1 randomisation
- Part of a trial evaluating four postresuscitation interventions
- Inclusion began June 2023; estimated 3-4 years
- Primary outcome analysed with Wilcoxon rank-sum test; medians with IQR and 95% CI for median difference
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Prophylactic Olanzapine Versus Placebo in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest ( DANOHCA ) Trial. Acta Anaesthesiol Scand. Published 23 June 2026. doi:10.
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