Cardiac arrest & resuscitation
The Danish Out‐of‐Hospital Cardiac Arrest Trial: A Statistical Analysis Plan
Study context
- Population
- Comatose adult out-of-hospital cardiac arrest (OHCA) patients with presumed cardiac etiology and sustained ROSC, randomised within 180 min of ROSC
- Planned comparison
- Dexamethasone vs placebo, olanzapine vs placebo, backrest elevation 35° vs 5°, early (≤ 6 h) vs late (28-36 h) wakeup
- Primary endpoint
- 90-day all-cause mortality (dexamethasone and backrest interventions); days alive outside hospital within 30 days (olanzapine and early wakeup interventions)
Methodological detailsinvestigator-initiated, multicenter, 2 × 2 × 2 × 2 factorial, pharmacological interventions blinded, physiological interventions open-label, intention-to-treat, Analysis plan finalized prior to completion of randomization
- Investigator-initiated
- Multicenter
- 2 × 2 × 2 × 2 factorial
- Pharmacological interventions blinded
- Physiological interventions open-label
- Intention-to-treat
- Analysis plan finalized prior to completion of randomization
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
The Danish Out‐of‐Hospital Cardiac Arrest Trial: A Statistical Analysis Plan. Acta Anaesthesiol Scand. Published 23 June 2026. doi:10.
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