Cardiac arrest & resuscitation
Early Versus Late Wake‐Up Call After Out‐Of‐Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest ( Danish Out-of-Hospital Cardiac Arrest (DANOHCA) ) Trial
Study context
- Population
- Adults (≥ 18 years) with presumed cardiac-cause out-of-hospital cardiac arrest (OHCA), sustained ROSC and persistent unconsciousness on ICU admission
- Planned comparison
- Early vs late wake-up call
- Primary endpoint
- Days alive and out of hospital
- Follow-up
- 30 days after randomization
Methodological detailsDANOHCA, investigator-initiated, multicentre, 2 × 2 × 2 × 2 factorial, 1:1 randomisation, modified ITT analysis, Hypothesis: sedation for 28-36 h leads to more days alive outside hospital in 30 days vs sedation for ≤ 6 h
- DANOHCA
- Investigator-initiated
- Multicentre
- 2 × 2 × 2 × 2 factorial
- 1:1 randomisation
- Modified ITT analysis
- Hypothesis: sedation for 28-36 h leads to more days alive outside hospital in 30 days vs sedation for ≤ 6 h
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Early Versus Late Wake‐Up Call After Out‐Of‐Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest ( DANOHCA ) Trial. Acta Anaesthesiol Scand. Published 7 June 2026. doi:10.
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