Perioperative medicine & outcomes
Differential effects of sevoflurane and desflurane on frontal intraoperative electroencephalogram dynamics associated with postoperative delirium
Authors' conclusion
In normal patients without POD, sevoflurane demonstrates a higher power spectrum and prefrontal connectivity than desflurane. Furthermore, reduced frontal alpha power, coherence, and connectivity of intraoperative EEG could be associated with an increased risk of POD. These intraoperative EEG characteristics associated with POD are more noticeable in sevoflurane-induced anesthesia than in desflurane-induced anesthesia.
Study context
- Population
- Elderly patients under sevoflurane or desflurane anaesthesia30 with postoperative delirium (POD)
- Participants
- 148 participants
- Exposure
- Sevoflurane vs desflurane; delirium vs non-delirium within each anaesthetic
- Sevoflurane deliriumn = 17
- Sevoflurane non-deliriumn = 60reference
- Desflurane deliriumn = 13
- Desflurane non-deliriumn = 58reference
- Outcome
- Intraoperative EEG spectral power, coherence and PPC in relation to POD
Methodological detailssecondary EEG analysis, frontal four-channel EEG, bootstrap analysis
- Secondary EEG analysis
- Frontal four-channel EEG
- Bootstrap analysis
Main finding
As reported in the abstract
Intraoperative frontal EEG · maintenance of anaesthesia
- Without POD: sevoflurane higher pairwise phase consistency (PPC) from alpha to gamma bands vs desflurane
- p < 0.005
- Sevoflurane: delirium lower alpha-band PPC vs non-delirium
- p < 0.005
Observational data: associations, not effects.
Original publication
Differential effects of sevoflurane and desflurane on frontal intraoperative electroencephalogram dynamics associated with postoperative delirium. J Clin Anesth. Published 28 December 2023. doi:10.
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