Distinct diurnal temperature rhythm patterns in critical illness myopathy: secondary analysis of two prospective trials
Authors' conclusion
Heterogeneous phase shifts of diurnal temperature rhythms in CIM and no-CIM groups compared to healthy bed rest volunteers may indicate ICU-related circadian disruption.
Study context
- Population
- Critically ill Intensive Care Unit (ICU) patients with severe multiorgan failure, assessed for critical illness myopathy (CIM) by electrophysiological tests
- Participants
- 32 / 30 / 16
- Comparison
- CIM vs no-CIM critically ill patients, with healthy bed rest volunteers as reference
- CIMn = 32
- no-CIMn = 30
- Healthy bed restn = 16reference
- Primary endpoint
- Diurnal body temperature rhythm parameters (cosinor analysis: nadir timepoint, mesor, amplitude)
Primary result
As reported in the abstract
Diurnal temperature rhythm parameters
| Group | Value | Amplitude |
|---|---|---|
| CIM | 10:43 (interval 09:21, 12:22) nadir timepoint | 0.3 °C [0.2, 0.4] |
| no-CIM | 11:12 (interval 09:43, 13:30) nadir timepoint | 0.2 °C [0.2, 0.3] |
| Healthy bed rest | 5:03 (interval 3:22, 6:36) nadir timepoint | 0.5 °C [0.2, 0.6] |
Value
CIM10:43 (interval 09:21, 12:22) nadir timepoint
no-CIM11:12 (interval 09:43, 13:30) nadir timepoint
Healthy bed rest5:03 (interval 3:22, 6:36) nadir timepoint
Amplitude
CIM0.3 °C [0.2, 0.4]
no-CIM0.2 °C [0.2, 0.3]
Healthy bed rest0.5 °C [0.2, 0.6]
- CIM and no-CIM vs Healthy bed rest: P < 0.001
- CIM and no-CIM vs Healthy bed rest: P < 0.01
- CIM vs no-CIM: P = 0.041
- CIM vs no-CIM: P = 0.021
- CIM vs no-CIM: P = 0.017
Further findings
Median
| Outcome | CIM | no-CIM | P value |
|---|---|---|---|
| SOFA scoreCIM vs no-CIM | 12 | 12 | P = 0.39 |
Correlation of rhythm amplitude with muscle histology
- Higher temperature rhythm amplitude correlated negatively with M. vastus lateralis myocyte cross-sectional area
Original publication
Distinct diurnal temperature rhythm patterns in critical illness myopathy: secondary analysis of two prospective trials. Ann Intensive Care. Published 27 October 2025. doi:10.
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