Respiratory failure & ventilation
‘Do-not-intubate’ orders in patients assisted by noninvasive respiratory support for acute hypoxaemic failure caused by coronavirus disease 2019; a systematic review and meta-analysis
Authors' conclusion
In COVID-19 patients assisted through NIRS for hypoxaemic ARF, a DNI order was frequently issued and associated with a high in-hospital mortality.
Study context
- Population
- Hospitalised patients undergoing noninvasive respiratory support (NIRS) for hypoxaemic COVID-19-related acute respiratory failure
- Participants
- 6,645 patients · 31 observational studies
- Comparison
- DNI order vs full treatment
- DNIn = 1,590
- Outcome
- Pooled incidence of DNI orders and associated in-hospital mortality
Pooled result
As reported in the abstract
Incidence of DNI orders among NIRS patients
DNI order issued
summary estimate 25.4%
95% CI 20.0–31.1
Further pooled results
Summary estimate
| Outcome | DNI | Full treatment |
|---|---|---|
| In-hospital mortalityHigh between-study heterogeneity | 83.6% (95% CI 75.3–90.7) | 20.0% (95% CI 14.2–26.5) |
Original publication
‘Do-not-intubate’ orders in patients assisted by noninvasive respiratory support for acute hypoxaemic failure caused by coronavirus disease 2019; a systematic review and meta-analysis. Eur J Anaesthesiol Intensive Care. Published 11 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →