Hemodynamics, fluids & transfusion
Donation After Circulatory Death Liver Transplantation: Impact of Normothermic Machine Perfusion on Key Variables
Authors' conclusion
In DCD liver transplantation, use of NMP was associated with reduced incidence of PRS and decreased vasopressor and inotrope requirements at the time of allograft reperfusion compared to using SCS.
Study context
- Population
- DCD liver transplant recipients; veno-venous bypass not used
- Participants
- 226 recipients
- Exposure
- DCD-NMP vs DCD-SCS
- DCD-NMPn = 103
- DCD-SCSn = 123reference
- Outcome
- Post-reperfusion syndrome incidence
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Epinephrine bolus dose during reperfusion
P < 0.001
Vasopressin bolus dose during reperfusion
P < 0.001
RBC transfusion, post-reperfusion
P = 0.006
FFP transfusion, post-reperfusion
P < 0.001
Platelet transfusion, post-reperfusion
P = 0.008
RBC transfusion · first 24 hours postprocedure
P = 0.028
FFP transfusion · first 24 hours postprocedure
P < 0.001
Cryoprecipitate transfusion, post-reperfusion
P = 0.015
Cryoprecipitate transfusion · first 24 hours postprocedure
P = 0.031
| Outcome | DCD-NMP | DCD-SCS | P value |
|---|---|---|---|
| TXA administration, post-reperfusion | 3.9% (95% CI 1.1%–9.6%) | 13% (95% CI 5.7%–17.4%) | P = 0.018 |
Epinephrine infusion dose · anhepatic phase, reperfusion, up to 90 minutes after reperfusion
- Higher epinephrine infusion dose in DCD-SCS
Original publication
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