Hemodynamics, fluids & transfusion
Examining the Association Between Model for End-Stage Liver Disease 3.0 Scores and Intraoperative Blood Component Transfusion During Liver Transplant Surgery
Authors' conclusion
Preoperative MELD 3.0 is a robust independent predictor of intraoperative transfusion burden in OLT.
Study context
- Population
- Adult orthotopic liver transplantation (OLT) recipients52 men · 17 women
- Participants
- 69 participants
- Exposure
- Association of preoperative MELD 3.0 score with intraoperative blood component transfusion
- Outcome
- Total intraoperative blood component use
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Total intraoperative blood components
β
0.82 blood components
95% CI 0.48–1.2P ≤ 0.001
Each one-point increase in MELD 3.0 (univariable)
β
0.92
95% CI 0.48–1.4P < 0.001
Higher MELD 3.0 (multivariable) · adjusted for age, birth sex, indication, preoperative hemoglobin
- Median intraoperative transfusion volume (IQR 24-46), blood components
- 34
Observational data: associations, not effects.
Secondary outcomes
Estimated blood loss (EBL)
- Median EBL (IQR 3500-8000), mL
- 5500
MELD 3.0, transfusion and EBL by sex (subgroup)
- Median MELD, women vs men: 33 [26-36.5] vs 23 [13-36]
- P = 0.05
- Total transfusion, women vs men: 34 [24-45] vs 34 [24-46] units
- P = 0.82
- EBL, women vs men: 5500 [4425-7420] vs 5000 [2800-8000] mL
- P = 0.55
MELD 3.0, transfusion and EBL by indication (subgroup)
- Median MELD, hepatocellular carcinoma (HCC) 13 [8-17] vs alcohol-related 34 [19.8-38]
- P < 0.001
- Median MELD, HCC 13 [8-17] vs other 27 [21.5-32.5]
- P = 0.01
- Total blood components, HCC vs alcohol-related: 24 [14-44] vs 38 [27-46.8] units
- P = 0.04
- EBL did not differ significantly across indications
- P = 0.12
Original publication
Examining the Association Between Model for End-Stage Liver Disease 3.0 Scores and Intraoperative Blood Component Transfusion During Liver Transplant Surgery. Anesth Analg. Published 29 April 2026. doi:10.
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