Hemodynamics, fluids & transfusion
Viscoelastic versus conventional coagulation tests to reduce blood product transfusion in patients undergoing liver transplantation: A systematic review and meta-analysis
Authors' conclusion
Our meta-analysis demonstrated that VETs implementation was associated with reduced RBC and FFP consumption in liver transplantation patients without effects on mortality and hospital and ICU-LOS.
Study context
- Population
- Liver transplantation recipients, operating room17 studies (15 observational, 2 RCTs)
- Participants
- 5,345 recipients
- Comparison
- Viscoelastic test (VET)-guided vs CCT-guided coagulation management
- Outcome
- Mean number of transfused units for each blood product (RBC, fresh frozen plasma (FFP), platelets, cryoprecipitate)
Methodological detailsPRISMA guidelines, previously published protocol, Databases searched up to 30 January 2022
- PRISMA guidelines
- Previously published protocol
- Databases searched up to 30 January 2022
Pooled result
As reported in the abstract
Transfused units per blood product
VETs vs CCTsMean difference, RBC units (95% CI)P value
I2 = 61%
−1.40(−1.87 to −0.92)
P < 0.001VETs vs CCTsMean difference, FFP units (95% CI)P value
I2 = 98%
−2.98(−4.61 to −1.35)
P = < 0.001VETs vs CCTsMean difference, cryoprecipitate (95% CI)P value
I2 = 91%
2.71(0.84–4.58)
P = 0.005Further pooled results
Mortality, hospital length of stay (LOS) and intensive care unit (ICU) LOS
- No significant difference
Original publication
Viscoelastic versus conventional coagulation tests to reduce blood product transfusion in patients undergoing liver transplantation: A systematic review and meta-analysis. Eur J Anaesthesiol. Published 22 November 2022. doi:10.
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