Haemodynamics, fluids & transfusion
Phase-specific dynamics of coagulation factors V, VIII, and XIII during liver transplantation: insights from a prospective study
Authors' conclusion
This prospective analysis reveals distinct, phase-specific trajectories of FV, FVIII, and FXIII during liver transplantation.
Study context
- Population
- Liver transplant recipients receiving transfusion support without recombinant FVIII or FXIIIsubset analysed
- Participants
- 17 recipients
- Exposure
- Coagulation factor activities at T1, T2 and T3
- Outcome
- Intraoperative activities of FV, FVIII and FXIII and their temporal trends
Main finding
As reported in the abstract
FV, FVIII, FXIII activity
- FV at T1
- 37% (22/55)
- FV at T3 (vs T1, p = 0.0309)
- 26% (19/34)
- FVIII at T1 (supranormal)
- 193% (160/254)
- FVIII at T3 (near-normal; vs T1, p < 0.0001)
- 109% (67/143)
- FXIII at T1 (close to lower limit of normal)
- 68% (50/85)
- FXIII at T3 (no significant change)
- 63% (55/78)
Observational data: associations, not effects.
Original publication
Phase-specific dynamics of coagulation factors V, VIII, and XIII during liver transplantation: insights from a prospective study. Perioper Med (Lond). Published 6 May 2026. doi:10.
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