Cardiothoracic & vascular anesthesia
Development of New Donor-Specific and Human Leukocyte Antigen Antibodies After Transfusion in Adult Lung Transplantation
Authors' conclusion
Increased perioperative transfusion of platelets and cryoprecipitate are associated with de novo HLA and DSA development, respectively, in lung transplant recipients during the first year after transplantation.
Study context
- Population
- Adult lung transplant recipients transplanted September 2014–June 2019, single academic tertiary center
- Participants
- 380 recipients
- Exposure
- Perioperative blood product transfusion (first 72 h) and development of de novo HLA antibodies and donor-specific antibodies (DSAs)
- DSAn = 87
- HLAn = 85
- Negativen = 208reference
- Outcome
- Transfusion and de novo HLA antibody / DSA development
- Follow-up
- First year after transplantation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Each group vs negativeOdds ratio (95% CI)P value
HLAplatelet transfusion; multivariate analysis
1.18(1.02–1.36)
P = 0.025DSAcryoprecipitate transfusion, 1 v 0 units
2.21(1.32–3.69)
P = 0.002Observational data: associations, not effects.
Further findings
Factors associated with HLA and DSA development
- Donor pulmonary infection, non-infectious indication for transplant, increased recipient BMI and preoperative calculated panel reactive antibody >0 associated with increased HLA and DSA development
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Development of New Donor-Specific and Human Leukocyte Antigen Antibodies After Transfusion in Adult Lung Transplantation. J Cardiothorac Vasc Anesth. Published 29 April 2023. doi:10.
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