Dual titration of minute ventilation and sweep gas flow to control carbon dioxide variations in patients on venovenous extracorporeal membrane oxygenation
Authors' conclusion
Implementation of our protocol for dual titration of minute ventilation and sweep gas flow was feasible and associated with less initial PaCO2 variation than usual care. It was also associated with less intracranial bleeding.
Study context
- Population
- Patients requiring VV-ECMO for severe ARDS, single unit, March 2020 to May 2021
- Participants
- 51 patients
- Exposure
- Protocol vs Control
- Protocoln = 27
- Controln = 24reference
- Outcome
- Mean absolute change in PaCO2 in consecutive arterial blood gas samples
- Follow-up
- First 12 h after VV-ECMO implantation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
12 h
P = 0.007
Observational data: associations, not effects.
Secondary outcomes
Large (> 25 mmHg) initial PaCO2 variations · immediately after ECMO implantation
P = 0.04
Mortality
P = 0.42
Feasibility
- The protocol was proved feasible
Safety
Intracranial bleeding
P = 0.04
Original publication
Dual titration of minute ventilation and sweep gas flow to control carbon dioxide variations in patients on venovenous extracorporeal membrane oxygenation. Ann Intensive Care. Published 25 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →