Mechanical ventilation settings during weaning from venovenous extracorporeal membrane oxygenation
Main finding · 90-day probability of successful weaning from mechanical ventilationResult — go to the resultSHR for successful weaning from mechanical ventilation 1.23 95% CI 0.84–1.82Authors' conclusion
Time to successful weaning from mechanical ventilation within 90 days post-ECMO was not associated with the mechanical ventilation strategy used during SGOT.
Study context
- Population
- Adults with severe ARDS successfully weaned from VV ECMO, two tertiary ICUs (high-volume ECMO centres) in France and Italy, over 7 years
- Participants
- 101 vs 292
- Exposure
- Spontaneous breathing vs Controlled ventilation
- Spontaneous breathingn = 101
- Controlled ventilationn = 292
- Outcome
- Time to successful weaning from mechanical ventilation
- Follow-up
- Within 90 days post-ECMO weaning
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
90-day probability of successful weaning from mechanical ventilation · 90 days post-ECMO weaning
SHR for successful weaning from mechanical ventilation
1.23
95% CI 0.84–1.82
Spontaneous breathing vs Controlled ventilation
sHR for successful weaning from mechanical ventilation 1.23 (95% CI 0.84–1.82)
Observational data: associations, not effects.
Further findings
Independent predictors of lower probability of successful weaning from mechanical ventilation (adjusted)
- Older age, higher pre-ECMO SOFA score, pneumothorax, VAP and RRT, but not ventilation modality during sweep gas-off trial (SGOT), independently associated with lower probability of successful weaning
Safety
ECMO-related complications
- Not statistically different between the two ventilation strategies
Original publication
Mechanical ventilation settings during weaning from venovenous extracorporeal membrane oxygenation. Ann Intensive Care. Published 4 September 2024. doi:10.
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