Respiratory failure & ventilation
Modification of Respiratory Drive and Lung Stress by Level of Support Pressure and Extracorporeal Membrane Oxygenation (ECMO) Sweep Gas Flow in Patients With Severe COVID-19–Associated Acute Respiratory Distress Syndrome: an Exploratory Retrospective Analysis
Authors' conclusion
In patients with CARDS on pressure support ventilation, even moderate support pressure may lead to overassistance during assisted ventilation, which is only reflected by advanced monitoring of respiratory mechanics. Modifying carbon dioxide removal via the extracorporeal system profoundly affects respiratory effort and mechanics.
Study context
- Population
- Spontaneously breathing patients with severe COVID-19-associated acute respiratory distress syndrome (ARDS) (CARDS) on venovenous ECMO, university hospital
- Participants
- 10 participants
- Exposure
- Titrated support pressure and titrated ECMO sweep gas flow
- Outcome
- Respiratory drive (P0.1) and lung stress (total swing of transpulmonary pressure)
Methodological detailssingle-centre, exploratory
- Single-centre
- Exploratory
Main finding
As reported in the abstract
Respiratory drive and lung stress
- Increased support pressure decreased P0.1 but increased transpulmonary driving pressure, airway pressure, tidal volume and end-inspiratory transpulmonary occlusion pressure
- Increased ECMO sweep gas flow lowered P0.1, transpulmonary pressures, tidal volume and respiratory frequency linearly
Observational data: associations, not effects.
Original publication
Modification of Respiratory Drive and Lung Stress by Level of Support Pressure and ECMO Sweep Gas Flow in Patients With Severe COVID-19–Associated Acute Respiratory Distress Syndrome: an Exploratory Retrospective Analysis. J Cardiothorac Vasc Anesth. Published 1 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →