Respiratory failure & ventilation
Dyspnea as a marker of prognosis in immunocompromised patients with acute respiratory failure
Authors' conclusion
In immunocompromised patients admitted to the ICU for AHRF, dyspnea at admission is moderate to severe and is associated with clinical outcomes. Dyspnea-NRS ≥5 is associated with an increase in intubation rate and hospital mortality.
Study context
- Population
- Immunocompromised patients with acute hypoxemic respiratory failure admitted to the intensive care unit (ICU)
- Participants
- 547 patients
- Comparison
- Dyspnea-NRS on ICU admission and clinical outcomes
- Primary endpoint
- Intubation (invasive mechanical ventilation) and hospital mortality by dyspnea-NRS on admission
Primary result
As reported in the abstract
Factors independently associated with intubation and hospital mortality
- Intubation rate
- 41 %
- Dyspnea-NRS ≥5 associated with intubation (OR)
- 2.61, p < 0.001
- High SOFA associated with intubation (OR per point)
- 1.10, p = 0.006
- Fungal infection associated with intubation (OR)
- 2.02, p = 0.020
- Hospital mortality
- 37 %
- Age associated with hospital mortality (OR per year)
- 1.02, P = 0.009
- SOFA score associated with hospital mortality (OR per point)
- 1.13, P < 0.001
- Dyspnea-NRS associated with hospital mortality (OR per point)
- 1.19, P < 0.001
Further findings
Dyspnea-NRS on ICU admission (0–10)
- Median dyspnea-NRS (IQR 4-7)
- 5
- Independently associated with dyspnea-NRS: immune defect unrelated to hematological malignancy, chronic HF, high SOFA, respiratory rate
- Linear regression
Original publication
Dyspnea as a marker of prognosis in immunocompromised patients with acute respiratory failure. Ann Intensive Care. Published 19 May 2026. doi:10.
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