Respiratory failure & ventilation
Factors associated with ICU mortality and long-term outcomes in immunocompromised patients admitted to the intensive care unit for acute respiratory failure
Authors' conclusion
Whereas in-ICU mortality of immunocompromised patients with acute respiratory failure was mainly driven by severity, poor outcomes at 6 months were mainly driven by performance status before ICU admission. Solid cancer was independently associated with both poor short as well as longer-term outcomes.
Study context
- Population
- Immunocompromised patients admitted to ICU for acute hypoxemic respiratory failureanalysed
- Participants
- 299 patients
- Primary endpoint
- Early factors (within 6 h of admission) associated with in-ICU mortality
Methodological detailsmultivariable analysis
- Multivariable analysis
Primary result
As reported in the abstract
Factors independently associated with in-ICU mortality
- In-ICU mortality rate
- 31% (94 patients)
- Solid cancer, aOR
- 2.92 [1.22-7.28] (95% CI)
- SOFA score at admission, aOR
- 1.29 [1.14-1.48]
- Extent of pulmonary infiltrates on chest X-ray, aOR
- 1.57 [1.17-2.15]
- Increased discomfort 1 h after start of noninvasive respiratory support, aOR
- 2.08 [1.12-3.85]
Further findings
Poor functional outcome (death or survival with poor performance status) in ICU survivors · 6 months
- Mortality rate at 6 months (all analysed)
- 49% (146 patients)
- Solid cancer, aOR
- 3.03 [1.33-9.09]
- Poor performance status before ICU admission, aOR
- 2.43 [1.03-5.88]
- Decision to forgo life-sustaining therapies, aOR
- 5.88 [2.17-20.00]
- 202 ICU survivors with performance status reported
Original publication
Factors associated with ICU mortality and long-term outcomes in immunocompromised patients admitted to the intensive care unit for acute respiratory failure. Ann Intensive Care. Published 30 October 2025. doi:10.
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