Respiratory failure & ventilation
Sex-based differences in intensive care unit (ICU) management and outcomes of immunocompromised patients: A post hoc analysis of the prospective multicenter multinational Efraim cohort
Authors' conclusion
In this post hoc analysis of immunocompromised adult ICU patients with hypoxemic respiratory failure, women and men received similar ICU interventions, and had similar outcomes.
Study context
- Population
- Immunocompromised adults with acute hypoxemic respiratory failure admitted to 68 ICUs in 16 countries, November 2015–July 2016
- Participants
- 1,536 adults
- Comparison
- Women vs men
- Womenn = 614
- Menn = 922reference
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
ICU interventions and outcomes
- ICU supportive interventions (mechanical ventilation, vasopressors, renal replacement, bronchoalveolar lavage, ARDS adjuncts) similar between men and women
- Mortality in ICU, in hospital and at 90 days similar between men and women
Further findings
Factors associated with mechanical ventilation (adjusted)
| Estimate | P value | ||
|---|---|---|---|
| Female sexAdjusted analysis | sub-hazard ratio 1.19 (95 % CI 1.05–1.36) | P = 0.007 | |
| SOFA score on ICU day 1Adjusted analysis | sHR 1.16 (95 % CI 1.12–1.19) | P < 0.001 | |
| Chronic kidney diseaseAdjusted analysis | sHR 0.74 (95 % CI 0.59–0.93) | P = 0.009 | |
| 0.512Ratio (log scale) |
| Outcome | Women | Men | P value |
|---|---|---|---|
| SOFA score on first ICU day | 6 (IQR 4–10) | 7 (IQR 4–10) | P = 0.0005 |
Factors associated with hospital mortality
- Age, performance status and SOFA score on ICU day 1 associated with hospital mortality
Baseline characteristics
- Similar age, BMI and diagnoses leading to immunosuppression; hematopoietic cell transplant more common in men
Original publication
Sex-based differences in ICU management and outcomes of immunocompromised patients: A post hoc analysis of the prospective multicenter multinational Efraim cohort. J Crit Care. Published 28 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →