Respiratory failure & ventilation
Recorded body height and sex differences in lung-protective ventilation among adults with ARDS: an 11-year single-centre cohort study
Authors' conclusion
In the simultaneous adjusted model, recorded height, but not recorded sex, was independently associated with VT/kg PBW.
Study context
- Population
- Adults (≥ 18 years) with Berlin-definition ARDS receiving mechanical ventilation for ≥ 72 h, RWTH Aachen University Hospital surgical ICU, January 2013 to December 2023527 in adjusted VT model
- Participants
- 798 adults
- Exposure
- Women vs men; recorded body height
- Womenn = 263
- Outcome
- Repeated-measure PBW-normalised tidal volume (VT/kg PBW), adjusted for recorded sex and centred recorded height
Methodological detailssingle-centre, linear mixed-effects models
- Single-centre
- Linear mixed-effects models
Main finding
As reported in the abstract
VT/kg PBW, simultaneous adjusted model
Female-sex coefficient
0.051 mL/kg PBW
95% CI −0.273 to 0.376; P = 0.756
Women vs Men · adjusted; 58,802 observations
Β per cm
−0.0342 mL/kg PBW
95% CI −0.0498 to −0.0185; P < 0.001
Recorded height (per cm) · inversely associated
Observational data: associations, not effects.
Further findings
VT/kg PBW, unadjusted
P < 0.001
VT adherence, unadjusted
P < 0.001
| Outcome | Female-sex coefficient (J·min⁻1·kg PBW⁻1) (95% CI) | P value |
|---|---|---|
| PBW-normalised mechanical power, adjusted model410 patients; 44,725 observations | −0.0158 (−0.0512 to 0.0196) | P = 0.384 |
Plateau and driving pressures, predicted-body-weight (PBW)-normalised mechanical power, unadjusted
- Higher in women than men
Original publication
Recorded body height and sex differences in lung-protective ventilation among adults with ARDS: an 11-year single-centre cohort study. J Intensive Care. Published 31 August 2026. doi:10.
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