Respiratory failure & ventilation
Dyspnea is related to clinical outcomes in patients weaning from invasive mechanical ventilation with tracheostomy: a multicenter prospective study
Authors' conclusion
Dyspnea in tracheostomized critically ill patients is common during weaning and associated with prolonged weaning, reduced weaning success, increased PTSD-symptoms and decreased HR-QoL after ICU discharge.
Study context
- Population
- Tracheostomized critically ill patients weaning from invasive mechanical ventilation, 13 hospitals in the Netherlands (excl. tracheostomy for airway obstruction, neuromuscular disease)130 (83%) successfully weaned
- Participants
- 156 patients
- Outcome
- Number of weaning days with dyspnea
Methodological detailsmulticentre, April 2023 to June 2024
- Multicentre
- April 2023 to June 2024
Main finding
As reported in the abstract
Weaning days with dyspnea per patient
Median days with dyspnea per patient
3 [2-6] days
Median weaning duration
10 [8-15] days
Patients affected by dyspnea
58%
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Estimate | P value |
|---|---|---|
| Weaning success | HR 0.37 | P < 0.001 |
| PTSD-related symptoms (IES-R) · 90 days post-ICU | linear regression coefficient (β) 2.42 | P = 0.02 |
| HR-QoL (EQ-5D utility score) · 90 days post-ICU | linear regression coefficient (β) −0.025 | P = 0.03 |
- Weaning success: dyspnea associated with longer weaning duration and reduced weaning success
Dyspnea severity (D-VAS)
- Median D-VAS score
- 6 [5-7]
Original publication
Dyspnea is related to clinical outcomes in patients weaning from invasive mechanical ventilation with tracheostomy: a multicenter prospective study. Crit Care. Published 8 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →