Respiratory failure & ventilation
Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients
Authors' conclusion
Dyssynchronous diaphragm contractions may impair diaphragm function during mechanical ventilation.
Study context
- Population
- Patients receiving invasive mechanical ventilation for pneumonia, septic shock, ARDS or acute brain injury
- Participants
- 45 patients · 4,508 hourly recordings
- Outcome
- Association of dyssynchronous post-inspiratory diaphragm loading with decline in diaphragm function (neuromuscular coupling, NMC: transdiaphragmatic pressure/diaphragm electrical activity)
Methodological detailshourly recordings up to 7 days, retrospectively registered
- Hourly recordings up to 7 days
- Retrospectively registered
Main finding
As reported in the abstract
- Duration and magnitude of dyssynchronous post-inspiratory loading associated with progressive decline in diaphragm neuromuscular coupling (NMC)
- p < 0.01 for interaction with time
Observational data: associations, not effects.
Further findings
Predictors of dyssynchronous post-inspiratory loading
| OR (95% CI) | ||
|---|---|---|
| Reverse triggering | 15 (8–35) | |
| Premature cycling | 8 (6–10) | |
| 0.050.21520Odds ratio (log scale) |
Edi low or absent (≤ 5 µV)
- Proportion of study hours
- 51%
- Hours per patient, median (IQR)
- 71 h (39-101 h)
Dyssynchronous post-inspiratory loading
- Proportion of study hours
- 13%
- Hours per patient, median (IQR)
- 7 h (2-22 h)
Original publication
Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients. Crit Care. Published 2 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →