Respiratory failure & ventilation
Early physiologic changes after awake prone positioning predict clinical outcomes in patients with acute hypoxemic respiratory failure
Primary result · ROX index (main physiologic predictor)Result — go to the resultOdds ratio 0.37 95% CI 0.25–0.54Authors' conclusion
Relative changes in the ROX index within 6 h of the first awake prone positioning session along with other known predictive factors are associated with intubation and mortality at day 7.
Study context
- Population
- Adults with COVID-19-related acute respiratory failure treated with awake prone positioning
- Participants
- 244 adults
- Comparison
- Treatment failure vs no failure after awake prone positioning
- Failuren = 71
- Primary endpoint
- Treatment failure (endotracheal intubation and/or death) predicted by relative changes in physiological variables within first 6 h of first awake prone positioning session
- Follow-up
- 7 days
Primary result
ROX index (main physiologic predictor)
Odds ratio
0.37
95% CI 0.25–0.54
Relative increase of ROX index vs baseline
OR 0.37 (95% CI 0.25–0.54)
Every 25% increase, as printed
As reported in the abstract
Further findings
Mean
| Outcome | Failure | No failure | P value |
|---|---|---|---|
| ROX index at baseline | 5 (SD 1.4) | 6.6 (SD 2.2) | P < 0.0001 |
| ROX index within 6 h of prone positioning · within 6 h | 5.6 (SD 1.7) | 8.7 (SD 2.8) | P < 0.0001 |
- Awake prone positioning failure rate · 7 days
- 29% · 71
Original publication
Early physiologic changes after awake prone positioning predict clinical outcomes in patients with acute hypoxemic respiratory failure. Intensive Care Med. Published 14 November 2024. doi:10.
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