Pediatric anesthesia & critical care

Early predictors of unfavorable outcomes in pediatric acute respiratory failure

J Intensive CarePublished Retrospective cohort study

Authors' conclusion

A significant proportion of pediatric patients with acute respiratory failure experienced unfavorable outcomes

Study context

Population
Children under 20 years admitted with acute respiratory diseases (July 2010–March 2022) receiving ventilatory support within the first 3 days of hospitalization, Japanese acute care hospitals
Participants
29,362 eligible children
Outcome
Composite unfavorable outcomes
Methodological detailsnational inpatient database
  • National inpatient database

Main finding

As reported in the abstract

Unfavorable outcomes

2663

9.1%

In-hospital death

669

2.3%

Discharged with new comorbidities

1994

6.8%

Observational data: associations, not effects.

Further findings

Predictors of unfavorable outcomes (logistic regression)

Older age, underlying conditions, pneumonia and low hospital volume associated with unfavorable outcomes after adjustment
  • Adjusted for covariates

Highest ventilatory support within first 3 days

Invasive ventilation
69.4%
NIV
1.0%
HFNC
29.7%

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Early predictors of unfavorable outcomes in pediatric acute respiratory failure. J Intensive Care. Published 2 December 2024. doi:10.1186/s40560-024-00763-x

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