Respiratory failure & ventilation
Early Prone Positioning As a Rescue Therapy for Moderate-to-severe Primary Graft Dysfunction After Bilateral Lung Transplant
Authors' conclusion
Early PP in LT recipients with moderate-to-severe PGD seems to be associated with better 28-day ventilator-free days, oxygenation, and driving pressure than late PP.
Study context
- Population
- Bilateral lung transplant (LT) recipients developing moderate-to-severe primary graft dysfunction (PGD) within 24 hours from ICU admission130 screened
- Participants
- 67 recipients
- Exposure
- Early prone positioning (PP) vs late PP vs supine position
- Early PPn = 24
- Late PPn = 18reference
- Supinen = 25
- Outcome
- 28-day ventilator-free days
- Follow-up
- 28 days
Methodological detailspropensity score-weighted analysis
- Propensity score-weighted analysis
Main finding
As reported in the abstract
Estimated effect for 1 ventilator-free day
8.23
P = 0.007
Supine · SE 2.97
Estimated effect
9.42
P < 0.001
early PP · SE 2.59
Observational data: associations, not effects.
Further findings
Oxygenation, driving pressure, static respiratory system compliance
- Early PP associated with better oxygenation, driving pressure and static respiratory system compliance vs late PP
Oxygenation · 72 hours after PGD diagnosis
- Better oxygenation with early PP vs supine
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Early Prone Positioning As a Rescue Therapy for Moderate-to-severe Primary Graft Dysfunction After Bilateral Lung Transplant. J Cardiothorac Vasc Anesth. Published 26 November 2024. doi:10.
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