ICU sedation, delirium & recovery
Early reduction in gut microbiota diversity in critically ill patients is associated with mortality
Authors' conclusion
Gut microbiota diversity decreased over time, associated with increased mortality. Fecal pH is an unreliable marker of gut microbiota change.
Study context
- Population
- Critically ill ICU patients
- Participants
- 96 patients
- Outcome
- Association between time-varying changes in gut microbiota diversity (Shannon index) and mortality
- Follow-up
- 60 days
Methodological detailsBayesian joint models
- Bayesian joint models
Main finding
As reported in the abstract
Shannon index decrease and hazard of death
Hazard of death per point decrease in Shannon index (fold increase)
1.99
95% CrI 1.04 to 4.51
Daily Shannon index change (mean)
−0.1 points
95% CrI −0.20 to −0.10
Deaths during follow-up
24 of 96
Observational data: associations, not effects.
Further findings
- Time-varying fecal pH not associated with changes in Shannon index
Original publication
Early reduction in gut microbiota diversity in critically ill patients is associated with mortality. Ann Intensive Care. Published 26 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →