Early renal recovery after acute kidney injury in patients on venoarterial extracorporeal membrane oxygenation: A retrospective study
Authors' conclusion
Only 43% of patients with severe pre-ECMO AKI had early renal recovery after VA-ECMO initiation.
Study context
- Population
- Adults with cardiogenic shock rescued by VA-ECMO and severe AKI before ECMO implantationover 7 years
- Participants
- 145 adults
- Exposure
- Early renal recovery vs no early renal recovery
- Early renal recoveryn = 63
- No early renal recoveryn = 82reference
- Outcome
- Early renal recovery (≥50% decrease in peak serum creatinine or weaning from RRT)
- Follow-up
- Within 7 days after ECMO onset
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Early renal recovery within 7 days after VA-ECMO onset · 7 days
Early renal recovery
63
events
No early renal recovery
82
events
Hazard ratio (95% CI)P value
Nephrotoxic antibiotics
0.35(0.21–0.59)
P < 0.001Median fluid balance, first 7 days of VA-ECMO
0.77(0.64–0.93)
P = 0.008Pre-ECMO AKI stage 3
0.36(0.20–0.64)
P < 0.001Median vasoactive-inotropic score
0.99(0.98,1.00)
P = 0.035- Proportion with early renal recovery
- 43%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Early renal recovery after acute kidney injury in patients on venoarterial extracorporeal membrane oxygenation: A retrospective study. J Crit Care. Published 2 August 2023. doi:10.
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