Early Surgery and Outcomes in Severe Burns: A Prospective Multicenter Observational Study
Main finding · 90-day mortalityResult — go to the resultAdjusted odds ratio 2.3 95% CI 1.2–4.1Authors' conclusion
Early surgical excision within 48 hours was associated with lower adjusted 90-day mortality in adults with severe burns
Study context
- Population
- Adults (≥18 y) admitted within 72 hours of injury with burns >20% TBSA, 6 French centres, December 2016-December 2022
- Participants
- 448 adults · 6 French centres
- Exposure
- Delayed vs early surgical excision
- Delayedn = 358
- Earlyn = 90reference
- Outcome
- All-cause mortality
- Follow-up
- 90 days
Methodological detailsmulticentre, AIPTW and targeted maximum likelihood estimation
- Multicentre
- AIPTW and targeted maximum likelihood estimation
Main finding
90-day mortality
Adjusted odds ratio
2.3
95% CI 1.2–4.1
P = 0.007
Delayed vs Early
aOR 2.3 (95% CI 1.2–4.1); P = 0.007
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Early | Delayed | aOR (95% CI) | P value | |
|---|---|---|---|---|---|
| ICU mortality | 3.1 (1.5–6.3) | P = 0.001 | |||
| 28-day mortality | 2.9 (1.3–6.7) | P = 0.007 | |||
| Sepsis or septic shockMore often in the early group | 53% | 32% | 0.56 (0.38–0.83) | P = 0.004 | |
| 0.10.31310Adjusted odds ratio (log scale) |
Other secondary outcomes (organ failure, AKI, ARDS, secondary infections, ICU LOS)
- No significant differences
Original publication
Early Surgery and Outcomes in Severe Burns: A Prospective Multicenter Observational Study. Ann Surg. Published 18 August 2026. doi:10.
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