Respiratory failure & ventilation
Early versus Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation
Authors' conclusion
Early switching from controlled to assisted ventilation is associated with shorter duration of invasive mechanical ventilation and ICU stay compared with delayed switching.
Study context
- Population
- Critically ill patients on controlled invasive mechanical ventilation, not receiving neuromuscular blockers, with PaO2:FiO2 >150 mm Hgmet switching eligibility criteria
- Participants
- 1,489 patients
- Exposure
- Early vs delayed switching from controlled to assisted ventilation
- Outcome
- Cumulative incidence of successful extubation
- Follow-up
- 28 days
Methodological detailsprospective global dataset (WEAN SAFE)
- Prospective global dataset (WEAN SAFE)
Main finding
As reported in the abstract
Successful extubation
Early-switch vs DelayedDifference in cumulative incidence (95% CI)P value
At Day 28
7%(0–13%)
P = 0.04- Over the 28-day period
- additional days successfully extubated (average) 4 days (95% CI 3–6); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Difference in cumulative incidence (95% CI) | P value | |
|---|---|---|---|
| ICU discharge · Day 28 | 11% (7–18%) | P < 0.001 | |
| −1001020Difference (linear scale) |
| Outcome | Additional days discharged (average) (days) (95% CI) | P value |
|---|---|---|
| Days discharged from ICU · 90 days | 7 (4–12) | P < 0.001 |
ICU mortality
- ICU mortality rates did not differ between the strategies
Original publication
Early versus Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation. Am J Respir Crit Care Med. Published 1 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →