Echocardiography Does not Reduce Mortality in Sepsis: A Re-Evaluation Using the Medical Information Mart for Intensive Care IV Dataset*
Main finding · 28-day mortalityResult — go to the resultAdjusted hazard ratio 1.09 95% CI 0.95–1.25Authors' conclusion
Echocardiography in sepsis was not associated with a reduction in 28-day mortality based on observational data.
Study context
- Population
- Adults ≥16 years with septic shock requiring vasopressor support within 48 hours of admission, Beth Israel Deaconess Medical Center ICU 2008–2019 (MIMIC-IV); excluding readmissions, coronary care/cardiovascular ICU, ST-elevation MI, cardiac arrest
- Participants
- 5,697 eligible admissions
- Exposure
- Echocardiography vs No echocardiography
- Echocardiographyn = 1,515
- Outcome
- Mortality
- Follow-up
- 28 days
Methodological detailsmarginal structural model, rolling entry matching, single-centre
- Marginal structural model
- Rolling entry matching
- Single-centre
Main finding
28-day mortality
Adjusted hazard ratio
1.09
95% CI 0.95–1.25
P = 0.24
Echocardiography vs No echocardiography
aHR 1.09 (95% CI 0.95–1.25); P = 0.24
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Changes in management within 4 hours of imaging
- Treatment changes: echocardiography patients
- 493 (33%)
- Treatment changes: matched controls
- 431 (29%)
- Most common intervention: fluid bolus
Original publication
Echocardiography Does not Reduce Mortality in Sepsis: A Re-Evaluation Using the Medical Information Mart for Intensive Care IV Dataset*. Crit Care Med. Published 20 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →