Pediatric anesthesia & critical care
ED50 and ED95 of remimazolam for loss of consciousness in young children: a dose-finding study for induction of anaesthesia
Authors' conclusion
A single i.v. bolus of remimazolam at estimated doses of 0.45-0.60 mg kg-1 for children aged 1-6 yr and 0.35-0.45 mg kg-1 for those aged 6-12 yr effectively induces loss of consciousness in children.
Study context
- Population
- Children aged 1–12 yr undergoing induction of GA
- Participants
- 120 children
- Comparison
- Single i.v. bolus remimazolam ED50 and ED95 across three paediatric age groups
- Toddlern = 40
- Preschooln = 40
- School-agen = 40
- Outcome
- ED50 and ED95 of remimazolam for inducing loss of consciousness
Methodological detailsbiased coin design up-and-down method
- Biased coin design up-and-down method
Main finding
As reported in the abstract
ED50 and ED95 of remimazolam for loss of consciousness
| Group | ED50 | ED95 |
|---|---|---|
| Toddler | 0.42 (95% CI 0.37-0.44) | 0.57 (95% CI 0.48-0.59) |
| Preschool | 0.41 (95% CI 0.35-0.47) | 0.57 (95% CI 0.50-0.59) |
| School-age | 0.30 (95% CI 0.28-0.34) | 0.43 (95% CI 0.37-0.44) |
ED50
Toddler0.42 (95% CI 0.37-0.44)
Preschool0.41 (95% CI 0.35-0.47)
School-age0.30 (95% CI 0.28-0.34)
ED95
Toddler0.57 (95% CI 0.48-0.59)
Preschool0.57 (95% CI 0.50-0.59)
School-age0.43 (95% CI 0.37-0.44)
Safety
Hypotension, respiratory depression, bradycardia, other adverse events
- No significant cases in any of the three groups
Original publication
ED50 and ED95 of remimazolam for loss of consciousness in young children: a dose-finding study for induction of anaesthesia. Br J Anaesth. Published 18 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →