Effect of anterior quadratus lumborum block with ropivacaine on the immune response after laparoscopic surgery in colon cancer: a substudy of a randomized clinical trial
Authors' conclusion
Our study provides evidence that administration of bilateral anterior quadratus lumborum nerve block as a part of a multimodal analgesic regimen in an enhanced recovery after surgery for laparoscopic hemicolectomy in this cohort does not alter the systemic immune response.
Study context
- Population
- Patients undergoing laparoscopic hemicolectomy for colon cancer
- Participants
- 22 patients
- Comparison
- Bilateral anterior QL block with ropivacaine vs placebo
- Primary endpoint
- Systemic immune response: changes in blood transcript levels (n=750) and stimulated cytokine secretion (n=17) on ex vivo activation
- Follow-up
- First postoperative day
Methodological detailsdouble-blinded, exploratory substudy
- Double-blinded
- Exploratory substudy
Primary result
As reported in the abstract
Systemic immune response
- No effect of QL block on gene expression in immune cells (permutational multivariate analysis of variance: F=0.52)
- p=0.96
- No effect on abundances of major immune cell populations (Wilcoxon rank-sum test)
- p>0.05
- No effect on stimulated cytokine secretion (Wilcoxon rank-sum test)
- p>0.05
Original publication
Effect of anterior quadratus lumborum block with ropivacaine on the immune response after laparoscopic surgery in colon cancer: a substudy of a randomized clinical trial. Reg Anesth Pain Med. Published 9 November 2023. doi:10.
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