Cardiothoracic & vascular anesthesia
Effect of Glutamine Administration After Cardiac Surgery on Kidney Damage in Patients at High Risk for Acute Kidney Injury: A Randomized Controlled Trial
Authors' conclusion
Glutamine significantly decreased markers of kidney damage in cardiac surgery patients at high risk for AKI.
Study context
- Population
- Cardiac surgery patients at high risk for acute kidney injury (AKI) identified by high urinary [TIMP2]*[IGFBP7]
- Participants
- 64 patients
- Comparison
- IV glutamine vs saline control, continuously for 12 h postoperatively
- Primary endpoint
- Urinary [TIMP2]*[IGFBP7]
- Follow-up
- End of the 12-hour study period
Methodological detailsdouble-blind, pilot
- Double-blind
- Pilot
Primary result
As reported in the abstract
Urinary [TIMP-2]*[IGFBP7] · 12 h
Glutamine
0.18
median · IQR 0.09–0.29
Control
0.44
median · IQR 0.14–0.79
P = 0.01
Secondary outcomes
| Outcome | Glutamine | Control | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Overall AKI rate · within 72 hoursNot different among groups | 35.5% | 25.0% | 0.86% (0.62–1.20) | P = 0.419 | |
| 0.512Relative risk (log scale) |
- Overall AKI rate: 11/31 vs 8/32
KIM-1 and neutrophil gelatinase-associated lipocalin (NGAL) · 12 h
- Significantly lower in the glutamine group
Other secondary end points
- No differences
Original publication
Effect of Glutamine Administration After Cardiac Surgery on Kidney Damage in Patients at High Risk for Acute Kidney Injury: A Randomized Controlled Trial. Anesth Analg. Published 29 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →