Hemodynamics, fluids & transfusion
The effect of goal-directed crystalloid versus colloid administration on postoperative spirometry parameters: a substudy of a randomized controlled clinical trial
Authors' conclusion
Postoperative pulmonary function parameters were similarly impaired in patients receiving goal-directed crystalloid administration as compared to goal-directed colloid administration during open abdominal surgery.
Study context
- Population
- Patients undergoing major open abdominal surgery
- Participants
- 60 patients
- Comparison
- Goal-directed crystalloid vs colloid
- Crystalloidn = 31reference
- Colloidn = 29
- Primary endpoint
- Postoperative spirometry (FVC, FEV1, PEF)
- Follow-up
- 6 h postoperatively
Methodological detailspreplanned substudy, single-centre, blinded outcome assessment, Bedside spirometry preoperatively and 6, 24 and 48 h postoperatively
- Preplanned substudy
- Single-centre
- Blinded outcome assessment
- Bedside spirometry preoperatively and 6, 24 and 48 h postoperatively
Primary result
As reported in the abstract
Pulmonary function parameters 6 h after surgery · 6 h
| Group | Value | FEV1 (l) | Peak expiratory flow (PEF) (l.sec-1) |
|---|---|---|---|
| Crystalloid | 1.6 (range 1.2-2 l) l | 1.1 (0.9-1.6 l) | 2 (1.5 - 3.6 l.sec −1) |
| Colloid | 1.9 (range 1.5-2.4 l) l | 1.4 (1.2-1.7 l) | 2.3 (1.8 - 3.4 l.sec −1) |
Value
Crystalloid1.6 (range 1.2-2 l) l
Colloid1.9 (range 1.5-2.4 l) l
FEV1 (l)
Crystalloid1.1 (0.9-1.6 l)
Colloid1.4 (1.2-1.7 l)
Peak expiratory flow (PEF) (l.sec-1)
Crystalloid2 (1.5 - 3.6 l.sec −1)
Colloid2.3 (1.8 - 3.4 l.sec −1)
- Crystalloid vs Colloid: P = 0.15
- Crystalloid vs Colloid: P = 0.18
- Crystalloid vs Colloid: P = 0.23
Further findings
Total intraoperative fluid requirements
P = 0.01
Longitudinal time × group interactions of forced vital capacity (FVC), FEV1, PEF · 6 to 48 h postoperatively
- Did not differ significantly
Original publication
The effect of goal-directed crystalloid versus colloid administration on postoperative spirometry parameters: a substudy of a randomized controlled clinical trial. Perioper Med (Lond). Published 15 April 2024. doi:10.
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