Hemodynamics, fluids & transfusion
Revisiting the fluid challenge and stroke volume optimisation after induction of general anaesthesia
Authors' conclusion
Differences in effectiveness between crystalloid and colloid fluid when providing repeated FCs increase the risk of false negative indications of fluid non-responsiveness when crystalloid is used.
Study context
- Population
- Patients just after induction of GA
- Participants
- 111 participants
- Comparison
- Crystalloid vs colloid fluid challenges
Primary result
As reported in the abstract
SV increase after three FCs
Crystalloid
2.5%
median
Colloid
29.2%
median
P < 0.001
Further findings
BV expansion
P < 0.001
| Outcome | Crystalloid | Colloid | P value |
|---|---|---|---|
| ΔSV%/ΔBV% ratio | 0.12 | 0.98 | P < 0.001 |
Cardiac response to first fluid challenge (FC) and oxygen delivery
- Falsely low in both groups due to reflex redistribution of interstitial fluid into the circulation after anaesthetic induction
Original publication
Revisiting the fluid challenge and stroke volume optimisation after induction of general anaesthesia. Ann Intensive Care. Published 22 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →