Cardiothoracic & vascular anesthesia
The effect of high-dose selenium on mortality and postoperative organ dysfunction in post-cardiotomy cardiogenic shock patients supported with mechanical circulatory support – A post-hoc analysis of the SUSTAIN CSX trial
Authors' conclusion
In this explorative study, a perioperative high-dose selenium-supplementation did not show beneficial effects on organ dysfunctions and mortality rates in patients with PCCS receiving tMCS.
Study context
- Population
- Cardiac surgery patients with post-cardiotomy cardiogenic shock (PCCS) treated with temporary mechanical circulatory support (tMCS)
- Participants
- 39 patients
- Comparison
- High-dose selenium vs placebo
- Primary endpoint
- Duration of tMCS therapy
Methodological detailspost-hoc analysis, explorative, placebo-controlled
- Post-hoc analysis
- Explorative
- Placebo-controlled
Primary result
As reported in the abstract
Duration of tMCS
P = 0.52
Secondary outcomes
Dialysis duration · longer in the selenium group
P = 0.048
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The effect of high-dose selenium on mortality and postoperative organ dysfunction in post-cardiotomy cardiogenic shock patients supported with mechanical circulatory support – A post-hoc analysis of the SUSTAIN CSX trial. J Crit Care. Published 2 July 2024. doi:10.
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