Effect of an oxytocin protocol on secondary uterotonic use in patients undergoing Cesarean delivery
Main findingResult — go to the resultOdds ratio 1.33 95% CI 1.04–1.70Authors' conclusion
Patients in the modified rule of threes oxytocin protocol group were more likely to receive a secondary uterotonic than those in the preprotocol group. Estimated blood loss and transfusion outcomes were similar.
Study context
- Population
- Patients undergoing Cesarean deliveryCesarean deliveries in 3,637 patients
- Participants
- 4,010 patients
- Exposure
- Postprotocol vs Preprotocol
- Postprotocoln = 1,748
- Preprotocoln = 2,262reference
- Outcome
- Secondary uterotonic use
Main finding
As reported in the abstract
Odds ratio
1.33
95% CI 1.04–1.70
P = 0.02
Postprotocol vs Preprotocol
OR 1.33 (95% CI 1.04–1.70); P = 0.02
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Estimated blood loss greater than 1,000 mL | 0.64 (0.50–0.84) | P = 0.001 | |
| 0.512Odds ratio (log scale) |
Blood transfusion
- Postprotocol less likely to receive a blood transfusion
Composite of transfusion or hemoglobin < 8 g·dL-1
- Similar in the two groups
- OR 0.86 (95% CI 0.66 to 1.11; P = 0.25)
Original publication
Effect of an oxytocin protocol on secondary uterotonic use in patients undergoing Cesarean delivery. Can J Anaesth. Published 6 June 2023. doi:10.
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