Respiratory failure & ventilation
Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients With Impaired Consciousness: A Multicenter Randomized Controlled Trial
Primary resultResult — go to the resultMean difference −13.69 % 95% CI −24.86 to −2.52Authors' conclusion
In patients with impaired consciousness who are mechanically ventilated, 5 days of CHFO treatment was shown to significantly reduce nonaerated lung tissue.
Study context
- Population
- Adults with impaired consciousness (GCS ≤ 8) requiring invasive mechanical ventilation, 11 hospitals in China5 per group excluded from primary analysis
- Participants
- 80 adults
- Comparison
- Continuous high-frequency oscillation (CHFO) vs usual care
- Primary endpoint
- Percent change in nonaerated lung tissue on CT from baseline
- Follow-up
- Day 5
Methodological detailsmulticentre, single-anonymized
- Multicentre
- Single-anonymized
Primary result
As reported in the abstract
Mean difference
−13.69 %
95% CI −24.86 to −2.52
P = 0.017
By group
CHFO
−51.3%
95% CI −62.7–-40.0
Usual care
−37.6%
95% CI −49.3–-26.0
CHFO vs Usual care
mean difference −13.69 % (95% CI −24.86 to −2.52); P = 0.017
Further findings
Ventilator-free days, clinical pulmonary infection score, ICU LOS
- CHFO: more ventilator-free days, lower clinical pulmonary infection score, shorter ICU stay
Safety
- No adverse events of interest observed
Original publication
Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients With Impaired Consciousness: A Multicenter Randomized Controlled Trial. Chest. Published 20 September 2025. doi:10.
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