Cardiothoracic & vascular anesthesia
Effect of del Nido Cardioplegia on Isolated Coronary Artery Bypass Grafting: A Study-level Meta-analysis
Authors' conclusion
In patients undergoing isolated CABG, del Nido cardioplegia provides comparable mortality compared with other cardioplegic solutions.
Study context
- Population
- Patients undergoing isolated coronary artery bypass grafting (CABG)24 studies (4 RCTs, 5 PSM)
- Participants
- 34,737 patients
- Comparison
- Del Nido cardioplegia vs other cardioplegic solutions
- Outcome
- Operative mortality and morbidities (major end points)
Methodological detailsstudy-level, random effects model, subgroup analyses by RCT, propensity score and multivariable analysis
- Study-level
- Random effects model
- Subgroup analyses by RCT, propensity score and multivariable analysis
Pooled result
As reported in the abstract
Operative mortality
- Del Nido vs Other solutions: P = 0.262
Further pooled results
| Outcome | Pooled OR (95% CI) | |
|---|---|---|
| Postoperative MISubgroup analyses also significant | 0.43 (0.24–0.77) | |
| Postoperative renal failureSubgroup analyses also significant | 0.61 (0.45–0.81) | |
| 0.20.5125Pooled odds ratio (log scale) |
Postoperative stroke, reoperation, deep wound infection, AF
- Comparable between the 2 groups
Original publication
Effect of del Nido Cardioplegia on Isolated Coronary Artery Bypass Grafting: A Study-level Meta-analysis. J Cardiothorac Vasc Anesth. Published 13 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →