Effect of dexmedetomidine on pulmonary function in obese patients undergoing laparoscopic surgery
Authors' conclusion
In obese patients undergoing laparoscopic surgery under general anesthesia, the use of dexmedetomidine can improve the lung compliance and OI of the patients, inhibit the inflammatory response of the lungs of the patients and thus have a certain protective effect on the lung function.
Study context
- Population
- Obese patients undergoing laparoscopic surgery under GA
- Participants
- 30 vs 30
- Comparison
- Dexmedetomidine vs saline
- Dn = 30
- Cn = 30reference
- Primary endpoint
- Pulmonary function (Cdyn, OI, A-aDO2, RI)
Primary result
As reported in the abstract
Pulmonary function · T2 (30 min after pneumoperitoneum) and T3 (10 min after pneumoperitoneum release)
- Group D had higher Cdyn and oxygenation index (OI) and lower A-aDO2 and respiratory index (RI) vs group C at T2 and T3
- Vs T1, A-aDO2 and RI higher and Cdyn and OI lower in both groups at T2 and T3
Further findings
Plasma IL-8 and IL-10 · T1 to T6
- Group D had lower IL-8 and higher IL-10 vs group C at each time point T1–T6
- IL-8 and IL-10 higher than T0 at T1–T6 in both groups
Times of surgery, anesthesia, CO2 pneumoperitoneum, eye-opening, end of surgery to extubation
- Not statistically significant between groups
Original publication
Effect of dexmedetomidine on pulmonary function in obese patients undergoing laparoscopic surgery. Perioper Med (Lond). Published 16 May 2024. doi:10.
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