Cardiothoracic & vascular anesthesia
Effect of Esketamine on Postoperative Delirium in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass: A Randomized Controlled Trial
Primary resultResult — go to the resultRelative risk 0.52 95% CI 0.28–0.91Authors' conclusion
A single dose of esketamine (0.25 mg/kg) injected intravenously before anesthesia induction reduced the incidence of delirium in relatively young patients with ASA grade Ⅱ or Ⅲ who underwent on-pump cardiac surgery.
Study context
- Population
- Adults, American Society of Anesthesiologists (ASA) II–III and New York Heart Association (NYHA) II–III, undergoing cardiac valve surgery with CPB116 included
- Participants
- 112 adults
- Comparison
- Esketamine 0.25 mg/kg IV before anaesthesia induction vs normal saline
- Esketaminen = 56
- Placebon = 56reference
- Primary endpoint
- Postoperative delirium (POD) (positive 3-minute confusion assessment method (CAM) or confusion assessment method for the intensive care unit (CAM-ICU), assessed twice daily)
- Follow-up
- 7 days after surgery
Methodological detailstriple-blind
- Triple-blind
Primary result
As reported in the abstract
Relative risk
0.52
95% CI 0.28–0.91
P = 0.018
Events by treatment group
Esketamine vs Placebo
RR 0.52 (95% CI 0.28–0.91); P = 0.018
Further findings
| Outcome | Placebo | RR (95% CI) | |
|---|---|---|---|
| Multiple episodes of delirium | 42.9% | 0.54 (0.28–0.92) | |
| 0.20.5125Relative risk (log scale) |
| Outcome | Placebo |
|---|---|
| Hyperactive delirium subtype | 39.3% |
Original publication
Effect of Esketamine on Postoperative Delirium in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass: A Randomized Controlled Trial. Anesth Analg. Published 6 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →