Cardiothoracic & vascular anesthesia
Flurbiprofen in the subglottic space to prevent postoperative sore throat after cardiac surgery: A randomized double-blind study
Authors' conclusion
Repeated administration of flurbiprofen through the subglottic port of tracheal tubes reduced the incidence of sore throat and hoarseness after cardiac surgery without evidence of complications.
Study context
- Population
- Patients aged 50–75 years, NYHA class I or II, undergoing elective cardiac surgery (myocardial revascularization or valve repair/replacement) under CPB68 analysed
- Participants
- 71 patients
- Comparison
- Flurbiprofen vs saline via subglottic port of the ETT
- Fn = 34
- Pn = 34reference
- Primary endpoint
- Postoperative sore throat (POST)
Methodological detailssingle-centre, prospective, double-blind, placebo-controlled
- Single-centre
- Prospective
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
POST and hoarseness
F
5.9%
2 of 34
Secondary outcomes
| Outcome | P value |
|---|---|
| Hoarseness by sex, control group (multivariable model)Women vs Men · hoarseness affected women less than men | P = 0.002 |
Severity scores (VAS and TPS for sore throat, HOAR for hoarseness) · all time points
- The two groups significantly differed at all time points
- In group P, mild to moderate symptoms significantly improved or disappeared 36 h after tracheal tube removal
Safety
Events
| Outcome | F | P |
|---|---|---|
| Adverse effects | 0 | 0 |
Original publication
Flurbiprofen in the subglottic space to prevent postoperative sore throat after cardiac surgery: A randomized double-blind study. J Clin Anesth. Published 1 March 2024. doi:10.
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