Respiratory failure & ventilation
Effect of external dead space removal on CO2 homeostasis in mechanically ventilated adult Covid‐19 patients
Authors' conclusion
Removal of external DS increased alveolar minute ventilation and CO2 elimination in Covid-19 patients with respiratory failure in the current study. This was associated with a decrease in PaCO2 .
Study context
- Population
- Mechanically ventilated adults with ARDS from Covid-19
- Participants
- 10 participants
- Exposure
- Before vs after removal of external dead space
- Outcome
- Effect of external DS removal on CO2 homeostasis (alveolar minute ventilation, CO2 elimination, PaCO2)
Methodological detailsbefore-after comparison, method validation vs in vitro reference
- Before-after comparison
- Method validation vs in vitro reference
Main finding
As reported in the abstract
CO2 homeostasis after external DS removal
- Alveolar minute ventilation and CO2 elimination improved, with unchanged respiratory rate and tidal volumes
- Increase in CO2 elimination associated with a decrease in PaCO2
Observational data: associations, not effects.
Further findings
Volumetric capnography estimate of external dead space (DS) vs in vitro measured DS
- Bias (mL)
- −9
- Lower limit of agreement (mL), 95% CI −60 to −20
- −40
- Upper limit of agreement (mL), 95% CI 1-40
- 21
- Percentage error
- 48%
Original publication
Effect of external dead space removal on CO2 homeostasis in mechanically ventilated adult Covid‐19 patients. Acta Anaesthesiol Scand. Published 24 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →