Respiratory failure & ventilation
Effects of extracorporeal CO2 removal on gas exchange and ventilator settings: a systematic review and meta-analysis
Authors' conclusion
ECCO2R effectively reduces PaCO2 and acidosis allowing for less invasive ventilation.
Study context
- Population
- Critically ill adult ICU patients with respiratory failure undergoing ECCO2R
- Participants
- 1,672 patients · 49 studies
- Comparison
- ECCO2R
- Outcome
- Changes in gas exchange and ventilator settings (mean of differences), and proportions for adverse events (AEs)
- Follow-up
- 24 h after ECCO2R initiation
Methodological detailssubgroup analyses for disease indication and technology
- Subgroup analyses for disease indication and technology
Pooled result
As reported in the abstract
Gas exchange and ventilator settings · 24 h after initiation
- Significant decrease in PaCO2, plateau pressure and tidal volume and increase in pH across all patient groups
- ARDS and lung transplant: PaO2/FiO2 ratio increased significantly; ventilator settings variable
- "Higher extraction" systems reduced PaCO2 and respiratory rate more efficiently
Further pooled results
Mortality (3 randomized controlled trials (RCTs))
- No effect on mortality demonstrated
ICU and hospital LOS (3 RCTs)
- Significantly longer ICU and hospital stay with ECCO2R
Safety
- Overall adverse event rate
- 19%
Original publication
Effects of extracorporeal CO2 removal on gas exchange and ventilator settings: a systematic review and meta-analysis. Crit Care. Published 30 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →