Respiratory failure & ventilation
Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation
Main findingResult — go to the resultHazard ratio 0.81 95% CI 0.68–0.96Authors' conclusion
The initiation of mechanical ventilation in patients with acute hypoxemic respiratory failure reduced the hazard of dying in this emulation of a target trial.
Study context
- Population
- Non-intubated patients with hypoxemic respiratory failure (SpO2/FiO2 ≤ 200 and SpO2 ≤ 97%) within the first 48-h of hypoxemia, without immediate reason for intubation792 intubated within 48 h
- Participants
- 2,996 patients
- Exposure
- Immediate initiation of invasive ventilation vs waiting
- Outcome
- One-year mortality
- Follow-up
- 1 year
Methodological detailssingle-center database (MIMIC-IV), stabilized inverse probability weights, weighted Cox models
- Single-center database (MIMIC-IV)
- Stabilized inverse probability weights
- Weighted Cox models
Main finding
As reported in the abstract
Hazard ratio
0.81
95% CI 0.68–0.96
P = 0.018
Intubation vs Waiting
HR 0.81 (95% CI 0.68–0.96); P = 0.018
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| 30-day mortality | 0.80 (0.64–0.99) | P = 0.046 | |
| 0.512Hazard ratio (log scale) |
Original publication
Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation. Crit Care. Published 10 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →